The Neubauer Lab

The Neubauer Lab is located at the University of Veterinary Medicine Vienna, within the Unit for Medical Biochemistry in the Centre for Biological Sciences.

Our research is focused on the JAK-STAT core cancer pathway. We explore the molecular functions of JAK kinases and STAT transcription factors to gain insights into mechanisms controlling cellular proliferation/survival, gene transcription and epigenetic regulation, in the context of cancer initiation and progression. Moreover, we focus on testing and developing new targeted cancer therapies, and have established expertise in generating and analyzing mouse models for translational cancer research.

Our research team is interested in understanding the role of the JAK-STAT core cancer pathway in two main disease entities, mature T cell leukemias/lymphomas (MaTCLs) and myeloproliferative neoplasms (MPNs). Specifically, our work focuses on studying the role of the oncogenic transcription factor, STAT5B, and modeling aggressive gain-of-function driver mutations in order to explore new therapeutic targeting options and identify novel disease biomarkers.

You can find out more about our research here.

We are proud to be a part of ‘Green Labs Austria’ to contribute to more sustainable and environmentally friendly research.

Funding